Evaluation of the Efficiency of Curcumin, Pomegranate Extract, and Photobiomodulation in the Management of Oral Lichen Planus
Abstract
Objective: This study evaluated the efficiency of pomegranate extract, curcumin medicaments, and photobiomodulation in the treatment of oral lichen planus (OLP).
Material and Methods: A total of 33 patients with OLP were arbitrarily divided into one of 3 treatment groups: Group I was given pomegranate extract, Group II was given curcumin (turmeric), and Group III was given photobiomodulation/Photodynamic Therapy (PDT). For six months, all patients were instructed to apply the specific topical medication topically four times a day. After receiving the medication, patients were prohibited from eating or drinking for at least an hour. Clinical measurements of the health impact profile (patients’ pain, lesion size, and oral health impact profile (OHIP)-14 score) were taken at baseline, three months, and six months. The data gathered were evaluated statistically.
Result: Between baseline and three to six months following therapy, there was a reduction in the sign score, pain score, OHIP-14 score, and lesion size in all the examined groups. There was improvement in symptoms for Group III, followed by Groups I and II, which was statistically significant. In all three groups, there was a statistically significant decrease in the Modified Oral Mucositis (MOMI) Index and Numerical Rating Scale (NRS) score from baseline to three and six months following treatment.
Conclusion: According to the current study, PDT and herbal remedies significantly reduce OLP symptoms, making them viable alternatives to corticosteroid treatment for OLP management.
Keywords
Full Text:
PDFReferences
Dhanvanth M, Maheswari TN. Topical herbal therapeutic formulation used in the management of oral potentially malignant disorders – a systematic review. J Indian Acad Oral Med Radiol 2022;34:223-7. doi: 10.4103/jiaomr.jiaomr_101_21.
Hegarty AM. Hodgson TA, Lewsey JD, Porter SR. Fluticasone propionate spray and betamethasone sodium phosphate mouthrinse: a randomized crossover study for the treatment of symptomatic oral lichen planus. J Am Acad Dermatol 2002;271–9. doi: 10.1067/mjd.2002.120922.
Zakaria M, Khashaba O. Diagnostic accuracy of the mean platelet volume in oral lichen Planus. J Arab Society Medical Research 2019;14:52–6. doi: 10.4103/jasmr.jasmr_11_19.
Gupta, S, Ghosh, S, Gupta S. Interventions for the management of oral lichen planus: a review of the conventional and novel therapies. Oral Dis 2017;23:1029-42. doi: 10.1111/odi.12634.
Shivu ME, Gupta N, Mulla M, Mulla M, Anand Bajoria A, Varshney A. Evaluation of turmeric, ashwagandha, and aloe vera in the management of oral lichen planus lesion. J Pharm Bioall Sci 2024;16:S2043-5. doi: 10.4103/jpbs.jpbs_1264_23.
Mostafa B, Zakaria M. Evaluation of combined topical ozone and steroid therapy in management of oral lichen planus. Open Access Maced J Med Sci 2018;6:879-4. doi: 10.3889/oamjms.2018.219.
Dissemond J. Oral lichen planus: an overview. Dermatol Treat 2004;15:136-40. doi: 10.1080/09546630410030720.
Radwan-Oczko, M. Zwyrtek E, Elżbieta Owczarek J, Szcześniak D. Psychopathological profile and quality of life of patients with oral lichen planus. J Applied Oral Sci 2018;26:1–9. doi: 10.1590/1678-7757-2017-0146.
Alrashdan MS, Cirillo N, McCullough M. Oral lichen planus: a literature review and update. Arch Dermatol Res 2016;308:539–51. doi: 10.1007/s00403-016-1667-2.
Tiwari S, Avinash A, Katiyar S, Iyer A, Jain S. Dental applications of ozone therapy: a review of literature. Saudi J Dental Res 2017;8:105-11. doi: 10.1016/j.sjdr.2016.06.005.
Nashat E, Ali A, Madkour G. Efficacy and safety of topical chamomile in treatment of Oral Lichen Planus. Adv Dental J 2021;3:101-8. doi: 10.21608/adjc.2021.73435.1096.
Thomas AE, Varma B, Kurup S, Jose R, Chandy ML, Kumar SP, et al. Evaluation of efficacy of 1% curcuminoids as local application in management of Oral Lichen Planus – interventional study. J Clin Diagn Res 2017;11:ZC89-93. doi: 10.7860/JCDR/2017/20898.9715.
Vučić V, Grabež M, Trchounian A, Arsić A. Composition and potential health benefits of pomegranate: a review. Curr Pharm Des 2019; 25:1817-1827. doi: 10.2174/1381612825666190708183941.
Amirchaghmaghi M, Pakfetrat A, Delavarian Z, Ghalavani H, Ghazi A. Evaluation of the efficacy of curcumin in the treatment of oral lichen planus: a randomized controlled trial. J Clin Diagn Res 2016;10:ZC1347. doi: 10.7860/JCDR/2016/16338.7870.
He Y, Deng J, Zhao Y, Tao H, Dan H, Xu H, et al. Efficacy evaluation of photodynamic therapy for oral lichen planus: a systematic review and meta-analysis. BMC Oral Health 2020;20:302 doi: 10.1186/s12903-020-01260-x.
Cosgarea R, Pollmann R, Sharif J, Schmidt T, Stein R, Bodea A et al. Photodynamic therapy in oral lichen planus: a prospective case-controlled pilot study. Sci Rep 2020;10:1667. doi: 10.1038/s41598-020-58548-9.
Raab O. Uber die Wirkung fluorescirender Stoffe auf Infusorien. Z Biol 1956;108:312-20.
Thongprasom K, Luangjarmekorn L, Sererat T, Taweesap W. Relative efficacy of fluocinolone acetonide compared with triamcinolone acetonide in treatment of oral lichen planus. J Oral Pathol Med 1992;21:456-8. doi: 10.1111/j.1600-0714.1992.tb00974.x.
Lavanya N, Jayanthi P, Rao UK, Ranganathan K. Oral lichen planus: an update on pathogenesis. J Oral Maxillofac Pathol 2011;15:127–32. doi: 10.4103/0973-029X.84474.
Ali S, Wahbi W. The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta-analysis. Oral Dis 2017;23:913-8. doi: 10.1111/odi.12631.
Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158:573-7. doi: 10.1111/j.1365-2133.2007.08370.x.
Mahapatra S, Hebbale M, Mhapuskar A, Halli R, Jadhav S. The efficacy of Punica granatum extract gel in the treatment of symptomatic oral lichen planus in an Indian population: a clinical study. Indian J Pharmacol 2024;56:84–90. doi: 10.4103/ijp.ijp_107_23.
Moayeri H, Rajabi A, Mohammadi M, Moghaddam SB. Effects of Curcumin on the treatment of oral lichen planus symptoms: a systematic review and meta-analysis study. BMC Oral Health 2024;24:104. doi: 10.1186/s12903-024-03873-y.
Khaitan T, Vishal, Kabiraj A, Sinha DK, Ranjan R, Singh R. Curcuma Longa in the Treatment of Symptomatic oral lichen planus: a non-randomized controlled trial. Indian J Dermatol 2022;67:478. doi: 10.4103/ijd.ijd_1065_20.
Nammour S, El Mobadder M, Jr. Brugnera A, Namour M, Houeis S, Heysselaer D, et al. Photobiomodulation therapy vs. corticosteroid for the management of erosive/ulcerative and painful oral lichen planus. Assessment of success rate during one-year follow-up: a retrospective study. Healthcare 2021;9:1137. doi: 10.3390/healthcare9091137.
Mahuli SA, Rai A, Shree P, Haque ZU, Mahuli AV. Efficacy of photobiomodulation in the management of oral Lichen Planus in comparison to topical corticosteroids: systematic review, meta-analysis, and GRADE-based assessment of certainty of evidence. J Stomatol Oral Maxillofac Surg 2024;125:101798. doi: 10.1016/j.jormas.2024.101798.
Roccon A, Cavallin F, Zanette G, Bacci C. Single session of laser photobiomodulation for symptom management of oral lichen planus: a retrospective study. Lasers Med Sci 2023;38:43. doi: 10.1007/s10103-023-03706-4.
Shirke KJ, Pathak J, Swain N, Patel S, Patel T, Jain M. Oral lichen planus–a brief review on treatment modalities. J Contemp Dent 2018;8:137-43. doi: 10.5005/jp-journals-10031-1238.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.