The Prevalence and Associated Factors of Group B Streptococcus Colonization in Pregnant Women at Da Nang Hospital for Women and Children
Abstract
Objective: This study aimed to determine the prevalence of Group B Streptococcus (GBS) colonization and investigate its associated factors among pregnant women at Da Nang Hospital for Women and Children.
Material and Methods: A retrospective cross-sectional study was conducted on 807 pregnant women at 35–37 weeks of gestation who underwent rectovaginal GBS culture screening from March 1, 2024, to February 28, 2025. Demographic and clinical characteristics were collected from medical records. Associations were analyzed using Chi-square/Fisher’s exact tests and logistic regression.
Results: The prevalence of GBS colonization was 12.1%. The statistically significant associated factors included: vaginitis (adjusted odds ratio [aOR]=4.90; p-value=0.014), gestational diabetes (aOR=2.53; p-value=0.045), and maternal age >35 years (aOR=1.95; p-value=0.043). No significant difference was recorded regarding residence (rural/urban), occupation, or amniotic membrane status.
Conclusion: Group B Streptococcus colonization was observed among pregnant women at Da Nang Hospital for Women and Children, with a prevalence comparable to that reported in previous studies. These findings highlight the importance of targeted screening strategies for pregnant women, particularly those of advanced maternal age, to reduce the risk of adverse maternal and neonatal outcomes.
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Centers for Disease Control and Prevention. Prevention of perinatal group B streptococcal disease: a public health perspective. MMWR Recomm Rep [serial on the Internet]. 1996 Aug 16 [cited 2025 Nov 4];45(RR-7):1-24. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/00043277.htm
Schrag S, Gorwitz R, Fultz-Butts K, Schuchat A. Prevention of perinatal group B streptococcal disease: revised guidelines from CDC. MMWR Recomm Rep [serial on the Internet]. 2002 Aug 16 [cited 2025 Nov 4];51(RR-11):1-22. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5111a1.htm
Gonçalves BP, Procter SR, Clifford S, Koukounari A, Paul P, Lewin A, et al. Estimation of country-level incidence of early-onset invasive group B Streptococcus disease in infants using Bayesian methods. PLoS Comput Biol 2021;17:e1009001.
American College of Obstetricians and Gynecologists. Prevention of group B streptococcal early-onset disease in newborns. ACOG Committee Opinion No. 797. Obstet Gynecol 2020;135:e51-72.
Luong PN, Le HT, Huynh TL, Nguyen XT. The infection of vaginal-rectal group B Streptococcus on pregnancy women and results of interventional treatments to prevent mother-to-child transmission at Can Tho Obstetric and gynecology Hospital. Can Tho J Med Pharm 2021;40:223-9. Vietnamese.
Pham TH, Nguyen HT. Prevalence of group B Streptococcus infections vaginal-rectal in pregnant women at 36-38 weeks and related factors at Military Hospital 87. Viet Nam Med J 2023;520:155-9.
Nguyen TH, Do TD, Bui DT, Nguyen PS, Hoang QH. Current situation of group B streptococcal infections in preterm premature rupture of membrane pregnant women from 22-34 weeks of gestation at Hanoi Obstetrics and Gynecology Hospital. Viet Nam J Obstet Gynecol 2023;21:63-8. Vietnamese.
Phung TL, Nguyen TH, Nguyen THL, Nguyen TTS. Gestational diabetes increased prevalence of group B Streptococcus colonization during pregnancy. Viet Nam J Obstet Gynecol 2021;19:54-60.
Pham TT, Pham TTH, Do TD, Duong TTG. Prevalence of group B Streptococcus colonisation and pregnancy outcomes of pregnant women at Hanoi Obstetrics and Gynecology Hospital. Viet Nam J Sci Technol 2023;65:8-11. Vietnamese.
Tran QH. Nghiencuu thuc trang nhiem lien cau khuan nhom B o phu nu co thai va hieu qua dieu tri bang khang sinh trong chuyen da phong lay truyen sang con tai Benh vien San Nhi Nghe An (2018-2019) [dissertation]. Hanoi: National Institute of Malariology, Parasitology and Entomology; 2020.
Darabi R, Tadi S, Mohit M, Sadeghi E, Hatamizadeh G, Kardeh B, et al. The prevalence and risk factors of group B Streptococcus colonization in Iranian pregnant women. Electron Physician 2017;9:4399-404.
Nguyen CV, Huynh NPT, Nguyen VD, Nguyen TMN. Group B Streptococcal infection in an obstetric population checked up at Can Tho Gynecology and obstetrics Hospital in 2023: prevalence and some associated factors. Can Tho J Med Pharm 2024;76:1-8.
Huynh HT, Lam DT, Trinh THC, Tran ND. The association between gestational diabetes mellitus and group B Streptococcus colonization in pregnant women at Phuong Chau International Hospital in Can Tho. Viet Nam Med J 2023;2:348-52.
Luong HT, Le VD, Trieu TP. Prevalence of gestational diabetes and related factors at Hanoi Obstetrics and Gynecology Hospital. Viet Nam Med J 2023;1B:162-6.
Nguyen VQH, Thai B, Dinh TH. Study on group B streptococcal infection in pregnant women from 36 weeks. Viet Nam J Obstet Gynecol 2023;21:34-40.
Chen J, Fu J, Du W, Liu X, Rongkavilit C, Huang X, et al. Group B Streptococcal colonization in mothers and infants in western China: prevalences and risk factors. BMC Infect Dis 2018;18:291.
Gizachew M, Tiruneh M, Moges F, Adefris M, Tigabu Z, Tessema B. Streptococcus agalactiae from Ethiopian pregnant women; prevalence, associated factors and antimicrobial resistance: alarming for prophylaxis. Ann Clin Microbiol Antimicrob 2019;18:3.
Vieira LL, Perez AV, Machado MM, Kayser ML, Vettori DV, Alegretti AP, et al. Group B Streptococcus detection in pregnant women: comparison of qPCR assay, culture, and the Xpert GBS rapid test. BMC Pregnancy Childbirth 2019;19:532.
Chen X, Cao S, Fu X, Ni Y, Huang B, Wu J, et al. The risk factors for group B Streptococcus colonization during pregnancy and influences of intrapartum antibiotic prophylaxis on maternal and neonatal outcomes. BMC Pregnancy Childbirth 2023;23:207.
American College of Obstetricians and Gynecologists. Pregnancy at age 35 years or older: obstetric care consensus no. 11. Obstet Gynecol 2022;140:348-66.
Nguyen VC, Nguyen THY. Research on the situation of group B Streptococcus infection and antibiotic resistance in 35-37 weeks pregnant women in Phuong Chau International Hospital in 2021-2022. Can Tho J Med Pharm 2022;55:166-72. Vietnamese.
Surve MV, Anil A, Kamath KG, Bhutda S, Sthanam LK, Pradhan A, et al. Membrane vesicles of Group B Streptococcus disrupt feto-maternal barrier leading to preterm birth. PLoS Pathog 2016;12:e1005816.
Yu F, Tang YT, Hu ZQ, Lin XN. Analysis of the vaginal microecological status and genital tract infection characteristics of 751 pregnant women. Med Sci Monit 2018;24:5338-45.
Edwards JM, Watson N, Focht C, Wynn C, Todd CA, Walter EB, et al. Group B Streptococcus (GBS) colonization and disease among pregnant women: a historical cohort study. Infect Dis Obstet Gynecol 2019;2019:5430493.
Jiménez-Escutia R, Vargas-Alcantar D, Flores-Espinosa P, Helguera-Repetto AC, Villavicencio-Carrisoza O, Mancilla-Herrera I, et al. High glucose promotes inflammation and weakens placental defenses against E. coli and S. agalactiae infection: protective role of insulin and metformin. Int J Mol Sci 2023;24:5243.
Field C, Bank TC, Spees CK, Germann K, Landon MB, Gabbe S, et al. Association between glycemic control and group B Streptococcus colonization among pregnant individuals with pregestational diabetes. Am J Reprod Immunol 2023;90:e13779.
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