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Home > Vol 41, No 4 (2023) > Nualla-Ong

Association between Glucose Metabolism and Oral Combined Contraceptive Pills or Cyclic Progestin in Thai Women with Polycystic Ovary Syndrome: A 3-year Observational Study

Atipath Nualla-Ong, Thanyarat Wongwananuruk, Surasak Angsuwathana, Kitirat Techatraisak, Manee Rattanachaiyanont, Prasong Tanmahasamut, Suchada Indhavivadhana, Panicha Chantrapanichkul

Abstract

Objective: To measure the difference in fasting blood glucose (FBG) among Thai women with polycystic ovary syndrome (PCOS), having received either oral combined contraceptive pills (OCP) or cyclic progestin, during 3 years of treatment. 
Materials and Methods: The data were collected by a retrospective chart review of women with PCOS, who had been treated at Siriraj Hospital before June 2019, backward to the year 2000. The patients were divided into two groups, according to their different treatments, namely: an OCP group and a cyclic progestin group. There were 44 cases in each group, and both groups had received complete hormonal treatment over 3 years. 
Results: The patients’ baseline characteristics showed a significantly lower body mass index (BMI) and waist circumference (WC) in the OCP group than in the cyclic progestin treatment group. After the 3-year period of treatment, the FBG differences in the OCP group and cyclic progestin treatment group were 3.4±8.4 and 3.6±8.5 mg/dL, respectively; which revealed no statistical significance. Additionally, the difference in the WC and metabolic profile between the studied groups after 3 years of treatment also revealed no significance. However, BMI presented a significant difference between the two hormonal regimens after 3 years of treatment (p-value=0.007), with higher differences in the OCP treatment group. 
Conclusion: There was no statistically significant difference in FBG between the beginning and at the third year of treatment found in both regimens of hormonal treatment in Thai PCOS women.  

 Keywords

cyclic progestin; fasting blood glucose; oral combined contraceptive pills; polycystic ovary syndrome

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References

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DOI: http://dx.doi.org/10.31584/jhsmr.2023920

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About The Authors

Atipath Nualla-Ong
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,
Thailand

Thanyarat Wongwananuruk
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,
Thailand

Surasak Angsuwathana
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,
Thailand

Kitirat Techatraisak
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,
Thailand

Manee Rattanachaiyanont
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,
Thailand

Prasong Tanmahasamut
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,
Thailand

Suchada Indhavivadhana
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,
Thailand

Panicha Chantrapanichkul
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,
Thailand

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Keywords COVID-19 SARS-CoV-2 Thailand Vietnam children computed tomography cross-cultural adaptation depression diabetes diabetes mellitus elderly hypertension knowledge mental health mortality prevalence quality of life reliability risk factors treatment validity
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