HPV Vaccination Decision-Making Stages and Associated Factors Among Young Men Who Have Sex with Men in Thailand
Abstract
Objective: To examine human papillomavirus (HPV) vaccination stages and identify key determinants of HPV vaccination decision stages among young Thai men who have sex with men.
Material and Methods: This cross-sectional study recruited 397 young men who have sex with men (YMSM) aged 18-26 years. Data collection utilized an electronic questionnaire covering general information, health and sexual risk behaviors, HPV knowledge and attitudes, self-efficacy, subjective norms, and contextual perceptions of the HPV vaccine. Multivariate multinomial logistic regression was used to analyze the factors associated with vaccination across three stages: unawareness, undecided, and decided to vaccinate.
Results: YMSM in Thailand fell into three HPV vaccination decision-making stages: 42.3% unaware/unengaged, 39.8% undecided, and 17.9% committed to vaccination. Subjective norms had the strongest influence: participants with higher norms were more likely to be committed to vaccinating versus the undecided (adjusted odds ratio [AOR]=5.56, 95% confident interval [CI]: 2.30-13.45) or unaware (AOR=2.54, 95% CI: 1.05-6.14). Positive attitudes increased the odds of a vaccination commitment versus undecided (AOR=4.85, 95% CI: 1.78-13.21) and unaware participants (AOR=4.58, 95% CI: 1.41-12.23). Higher self-efficacy was associated with vaccination commitment versus undecided (AOR=2.94, 95% CI: 1.01-8.51) and unaware participants (AOR=3.31, 95% CI: 1.17-9.37). Neither HPV knowledge nor contextual perceptions were significantly associated with the decision-making stages.
Conclusion: Subjective norms and positive attitudes were the primary drivers of HPV vaccination decisions among YMSM in Thailand. Interventions targeting social influences and attitude change may be more effective than knowledge-based approaches alone for promoting vaccine uptake in this population.
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Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, et al. Human Papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics. Rev Med Virol 2024;34:e2537.
Palefsky JM. Human papillomavirus infections: Epidemiology and disease associations 2020 [homepage on the Internet]. Waltham (MA): UpToDate Inc.; 2020 [cited 2020 Dec 3]. Available from: https://www.uptodate.com/contents/human-papillomavirus-infections-epidemiology-and-disease-associations?topicRef=8325&source=see_link.
Bruni L, Albero G, Serrano B, Mena M, Collado JJ, Gómez D, et al. Human papillomavirus and related diseases in thailand.summary report 10 march 2023. [monograph on the Internet] Barcelona: ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre); 2023. [cited 2025 Sep 4]. Available from: https://hpvcentre.net/statistics/reports/THA.pdf
Somia IKA, Teeratakulpisarn N, Jeo WS, Yee IA, Pankam T, Nonenoy S, et al. Prevalence of and risk factors for anal high-risk HPV among HIV-negative and HIV- positive MSM and transgender women in three countries at South-East Asia. Medicine 2018;97:e9898.
De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S. Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta- analysis. Int J Cancer 2009;124:1626-36.
Das S, Khan S, Shamshad MF, Shingadia H, Jaganathan R, Ali SR, et al. Human pillomavirus infection: current global scenario of disease burden and prevention strategies. Int J Health Sci 2022;6:2747-59. doi: 10.53730/ijhs.v6nS8.12634.
Gillison ML, Chaturvedi AK, Lowy DR. HPV prophylactic vaccines and the potential prevention of noncervical cancers in both men and women. Cancer 2008;113(Suppl 10):3036-46.
Chin-Hong PV, Vittinghoff E, Cranston RD, Buchbinder S, Cohen D, Colfax G, et al. Age-specific prevalence of anal human papillomavirus infection in HIV-negative sexually active men who have sex with men: the EXPLORE study. J Infect Dis 2004;190:2070-6.
Goldstone S, Palefsky JM, Giuliano AR, Moreira Jr ED, Aranda C, Jessen H, et al. Prevalence of and risk factors for human papillomavirus (HPV) infection among HIV-seronegative men who have sex with men. J Infect Dis 2011;203:66-74.
Prendes BL, Wang SJ, Groppo ER, Eisele DW, Palefsky JM. Oral human papillomavirus in men who have sex with men with anal squamous intraepithelial lesions. Head Neck 2016;38(Suppl 1):E399-405.
Hidalgo-Tenorio C, Ramírez-Taboada J, Gil-Anguita C, Esquivias J, Omar-Mohamed-Balgahata M, SamPedro A, et al. Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine in HIV-positive Spanish men who have sex with men (MSM). AIDS Res Ther 2017;14:1-12.
Chanprasertpinyo W, Rerkswattavorn C. Human papillomavirus (HPV) vaccine status and knowledge of students at a university in rural Thailand. Heliyon 2020;6:e04625.
Malathammarat R, Srisuriyawet R, Leelaknavira Y. Predictive factors of hpv vaccination intention among young men who have sex with men in chonburi province. J Mil Nurs 2022;23:540-50.
Wheldon CW, Eaton LA, Watson RJ. Predisposing, enabling, and need-related factors associated with human papillomavirus vaccination intentions and uptake among black and hispanic sexual and gender diverse adults in the USA. J Racial Ethn Health Disparities 2023;10:237-43.
Chen Q, Zhou T, Zhong X. Factors related to HPV vaccination intention among MSM in China: a bayesian network model. Int J Environ Res Public Health 2022;19:15532.
Wheldon CW, Daley EM, Buhi ER, Baldwin JA, Nyitray AG, Giuliano AR. HPV vaccine decision-making among young men who have sex with men. Health Educ J 2017;76:52-65.
Reiter PL, McRee AL, Katz ML, Paskett ED. Human papillomavirus vaccination among young adult gay and bisexual men in the United States. Am J Public Health 2015;105:96-102.
Kesten JM, Flannagan C, Ruane-McAteer E, Merriel SWD, Nadarzynski T, Shapiro G, et al. Mixed-methods study in England and Northern Ireland to understand young men who have sex with men’s knowledge and attitudes towards human papillomavirus vaccination. BMJ Open 2019;9:e025070.
Tatar O, Perez S, Naz A, Shapiro GK, Rosberger Z. Psychosocial correlates of HPV vaccine acceptability in college males: A cross-sectional exploratory study. Papillomavirus Res 2017;4:99-107.
Fishbein M. An integrative model for behavioral prediction and its application to health promotion. In: DiClemente RJ, Crosby RA, Kegler MC, editors. Emerging theories in health promotion practice and research. 2nd ed. San Francisco: Jossey-Bass/Wiley; 2009;p.215-34.
Weinstein ND, Sandman PM, Blalock SJ. The precaution adoption process model. The Wiley encyclopedia of health psychology 2020:495-506.
Waller J, Ostini R, Marlow LA, McCaffery K, Zimet G. Validation of a measure of knowledge about human papillomavirus (HPV) using item response theory and classical test theory. Prev Med 2013;56:35-40.
Wheldon CW, Buhi ER, Daley EM. Gay and bisexual men’s human papillomavirus vaccine intentions: a theory-based structural equation analysis. J Health Psychol 2013;18:1177-86.
Gutierrez Jr B, Leung A, Jones KT, Smith P, Silverman R, Frank I, et al. Acceptability of the human papillomavirus vaccine among urban adolescent males. Am J Mens Health 2013;7:27-36.
Wheldon CW, Daley EM, Buhi ER, Nyitray AG, Giuliano AR. Health beliefs and attitudes associated with HPV vaccine intention among young gay and bisexual men in the southeastern United States. Vaccine 2011;29:8060-5.
Stout ME, Christy SM, Winger JG, Vadaparampil ST, Mosher CE. Self-efficacy and HPV vaccine attitudes mediate the relationship between social norms and intentions to receive the HPV vaccine among college students. J Community Health 2020;45:1187-27.
Yao PY, Lin CY, Ko NY, Zou H, Lee CW, Strong C. Predicting human papillomavirus vaccine uptake in men who have sex with men the influence of vaccine price and receiving a HPV diagnosis. BMC Public Health 2022;22:28.
Lacombe-Duncan A, Newman PA, Baiden P. Human papillomavirus vaccine acceptability and decision-making among adolescent boys and parents: a meta-ethnography of qualitative studies. Vaccine 2018;36:2545-58.
Ratanasiripong NT, Sri-Umporn S, Kathalae D, Hanklang S, Ratanasiripong P. Human papillomavirus (HPV) vaccination and factors related to intention to obtain the vaccine among young college women in Thailand. J Health Res 2018;32:142-51.
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