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Risk Factors and Surgical Site Infection in Patients with Surgical Antibiotic Prophylaxis in the Indian Population: A Prospective Cohort Study

 
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1. Title Title of document Risk Factors and Surgical Site Infection in Patients with Surgical Antibiotic Prophylaxis in the Indian Population: A Prospective Cohort Study
 
2. Creator Author's name, affiliation, country Karthik Sankar; Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116,; India
 
2. Creator Author's name, affiliation, country Deepika Anbalagan; Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116,; India
 
2. Creator Author's name, affiliation, country Balaswetha Baskaran; Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116,; India
 
2. Creator Author's name, affiliation, country Vysali Segaran; Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116,; India
 
2. Creator Author's name, affiliation, country Yogitha Prabakar; Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116,; India
 
2. Creator Author's name, affiliation, country Sridhar Raghu; Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116,; India
 
2. Creator Author's name, affiliation, country Vidhya Krishna; Department of Pediatrics, Post-doctoral fellow in Infectious Diseases, Sri Ramachandra Medical College and Research Institute, Porur, Chennai 600116,; India
 
2. Creator Author's name, affiliation, country Venkatesan Singaram; Department of Engineering and Technology, Sri Ramachandra Faculty of Engineering and Technology, Porur, Chennai 600116,; India
 
2. Creator Author's name, affiliation, country Xavier Santhiyagu; Department of Statistics, Loyola College, Chennai, Tamilnadu 600034,; India
 
2. Creator Author's name, affiliation, country Muhasaparur Ganesan Rajanandh; Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu,; India
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) antibiotic prophylaxis; deep wound; superficial wound; surgical site infection
 
4. Description Abstract

Objective: To assess the risk factors and Surgical Site Infections (SSI) in patients with surgical antibiotic prophylaxis (SAP) within the Indian population.
Material and Methods: A prospective cohort study, consisting of 1,362 patients, with the age of 18 and above; admitted for various surgical procedures, and prescribed with SAP were included. In order to determine the significance of categorical data, the chi-square test, and Multiple binary logistic regression via the backward wald method was used to identify the risk factors. Various risk factors and their association to SSI were assessed, with a probability value of ≤0.05 being considered as a significant level.
Result: In total, 171 SSI were observed; with an incidence of 12.6% [95% CI=11.1-16.6] among all study patients (1,362). Cefotaxime was the most prescribed SAP in this study. In total 59.6% had gram-positive organisms and 40.4% had gram-negative organisms. Type of surgery, female gender, smoking and alcohol, diabetes with hypertension, microbial growth, American Society of Anesthesiologists (ASA) score (class III), hospital guidelines, and pre-operative hospital stays (>7 days) were the significant risk factors (p-value<0.05) associated with SSI. There was no significant association with drain use, nor redosing (p-value>0.05).
Conclusion: This study emphasizes the significant risk factors; such as age, female gender, types of surgery, ASA score, nonadherence to hospital guidelines, monomicrobial and polymicrobial growth and poor compliance to SAP being associated with SSI in surgical patients. These risk factors allow a better understanding related to SSI, which may have therapeutic implications.
 
5. Publisher Organizing agency, location Faculty of Medicine, Prince of Songkla University
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2023-09-18
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://www.jhsmr.org/index.php/jhsmr/article/view/971
 
10. Identifier Digital Object Identifier (DOI) http://dx.doi.org/10.31584/jhsmr.2023971
 
11. Source Title; vol., no. (year) Journal of Health Science and Medical Research; Vol 41, No 6 (2023): Nov-Dec
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2023 Journal of Health Science and Medical Research Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.