Indexing metadata

Association between Specific Single Nucleotide Polymorphisms, Clinical Features and Severe Hepatitis in Dengue Patients

 
Dublin Core PKP Metadata Items Metadata for this Document
 
1. Title Title of document Association between Specific Single Nucleotide Polymorphisms, Clinical Features and Severe Hepatitis in Dengue Patients
 
2. Creator Author's name, affiliation, country Sawangpong Jandee; Unit of Gastroenterology and Hepatology, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Teerha Piratvisuth; Unit of Gastroenterology and Hepatology, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand. Nanthana-Kriangkrai Chotiwattanaphan Institute of Gastroenterology and Hepatology, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Naichaya Chamroonkul; Unit of Gastroenterology and Hepatology, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Pimsiri Sripongpan; Unit of Gastroenterology and Hepatology, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Pisit Tangkijvanich; Research Unit of Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok 10330,; Thailand
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) dengue fever; dengue hemorrhagic fever; genetic susceptibility; hepatitis
 
4. Description Abstract

Objective: This study aimed to identify predictors associated with severe hepatitis, especially genetic features, among
dengue patients.
Material and Methods: One hundred seventy nine dengue patients from the years 2009-2014 were identified from
the hospital inpatient database. Their baseline characteristics, laboratory data and hospital course were recorded and
analyzed. Seventy five patients had been tested for specific single nucleotide polymorphisms either the Janus kinase 1 (Jak1) or the cluster of differentiation 209 genes.
Results: Most of the identified study patients were female (64.8%), 74.3% had elevated liver enzymes, 48.6% of whom showed mild hepatitis. Serum aspartate aminotransferase was predominate over serum alanine aminotransferase (ALT) in most patients. Myalgia was the most common initial presentation (65.4%). Severe hepatitis (ALT ≥10 times the upper limit of normal) was associated with a higher intensive care unit (ICU) admission rate (26.3%) and complications (36.8%). There was significant elevation of liver enzymes among patients with initial platelets <50,000/microliter and albumin <3.5 gram (g)%. An initial serum albumin <3.5 g% had an odds ratio=4.16, 95% confidence interval 1.41-12.27 in association with severe hepatitis. No difference in specific single nucleotide polymorphisms was found between the severe liver involvement group and the mild group.
Conclusion: Liver involvement among dengue infection is frequent, mostly manifesting as mild transaminitis. Patients with severe hepatitis usually have poorer clinical outcomes due to complications and often require ICU admission. Initial serum albumin <3.5 g% appears to be a predictor associated with severe hepatitis and bad outcomes. The genetic susceptibility needs more study.
 
5. Publisher Organizing agency, location Faculty of Medicine, Prince of Songkla University
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2020-05-15
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://www.jhsmr.org/index.php/jhsmr/article/view/734
 
10. Identifier Digital Object Identifier (DOI) http://dx.doi.org/10.31584/jhsmr.2020734
 
11. Source Title; vol., no. (year) Journal of Health Science and Medical Research; Vol 38, No 3 (2020): Jul-Sep
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2020 Journal of Health Science and Medical Research Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.