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Exploring Prevalence and Predictors of Clinically Suspected Dialysis Disequilibrium Syndrome in End-Stage Kidney Disease Patients Initiating Hemodialysis

 
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1. Title Title of document Exploring Prevalence and Predictors of Clinically Suspected Dialysis Disequilibrium Syndrome in End-Stage Kidney Disease Patients Initiating Hemodialysis
 
2. Creator Author's name, affiliation, country Budsarawadee Nookaew; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Ussanee Boonsrirat; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Suwikran Wongpraphairot; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Sirihatai Konwai; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Suntornwit Praditaukrit; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
2. Creator Author's name, affiliation, country Atthaphong Phongphithakchai; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,; Thailand
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) dialysis disequilibrium syndrome; end-stage kidney disease; hemodialysis; prevalence; risk factors; neurological symptoms
 
4. Description Abstract

Objective: This study aimed to examine the prevalence and predictors of clinically suspected dialysis disequilibrium syndrome (DDS) in end-stage kidney disease (ESKD) patients starting their first hemodialysis session.
Material and Methods: Data was retrospectively collected from a university hospital; from december 2020 to july 2023. It included adult patients receiving their first session of hemodialysis. Patient demographics, comorbidities, medications, and laboratory results were analyzed. The primary objective was to identify clinically suspected DDS using predefined criteria. Multivariate logistic regression was used to identify independent risk factors for clinically suspected DDS.
Results: A total of 106 patients were enrolled. Among these, 18.8% had clinically suspected DDS, with nausea being the most prevalent symptom. The onset of symptoms varied, with a median of 240 minutes. Multivariate analysis revealed higher pre-hemodialysis serum creatinine as a risk factor for DDS (adjusted OR: 1.13; 95% CI: 1.02–1.25), while lower pre-hemodialysis serum sodium (adjusted OR: 0.90; 95% CI: 0.84–0.98) and capillary blood glucose levels (adjusted OR: 0.99; 95% CI: 0.97–1.0) were associated with increased risk. Notably, elevated blood glucose levels were protective against DDS.
Conclusion: Higher pre-dialysis serum creatinine, coupled with lower sodium and glucose levels significantly predicts DDS. These findings emphasize the necessity of tailored hemodialysis prescriptions and vigilant monitoring of patients likely to develop DDS.
 
5. Publisher Organizing agency, location Faculty of Medicine, Prince of Songkla University
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2025-03-13
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://www.jhsmr.org/index.php/jhsmr/article/view/1120
 
10. Identifier Digital Object Identifier (DOI) http://dx.doi.org/10.31584/jhsmr.20241120
 
11. Source Title; vol., no. (year) Journal of Health Science and Medical Research; Vol 43, No 3 (2025): May-Jun
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2024 Journal of Health Science and Medical Research Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.